The pathogenetic role in vasculitis for:
B-cells, T-cells and antigen presenting cells
Endothelial cells
Cellular signalling, cytokines, receptors and effector pathways
Granulomas
Diagnostic criteria and classification
AASV
Other vasculitis
Treatment
How do we know what we are treating
How do we optimize treatment according to type of vasculitis Epidemiology
Genes
Microbes and environmental exposures
ANCA is not just ANCA
ANCA has antigen specificity
ANCA has epitope specificity for each antigen
ANCA has class and subclass specificities
ANCA detection for diagnostic purposes must be optimized
ANCA detection for diagnostic purposes must be optimized
ANCA detection to monitor disease activity or pathogenetic aspects may require
specific assays
Mechanisms for ANCA production
How is ANCA production initiated
How is ANCA production regulated
What is the significance of the concommitant presence of other autoantibodies
